Why is it important to determine the etiology of macrocytosis?

Updated: Dec 16, 2020
  • Author: Vincent E Herrin, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Diagnosis of the etiology of macrocytosis is required to guide treatment and determine the patient's prognosis. No complications are directly attributable to the increased size of the red cell; complications are attributed to the condition causing the macrocytosis. Failure to diagnose and treat the cause of the macrocytosis is a medicolegal pitfall. In addition to the conditions listed in the differential diagnosis, liver disease should also be considered.

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