What are the causes of folate deficiency leading to macrocytosis?

Updated: Dec 16, 2020
  • Author: Vincent E Herrin, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Folate also is needed as a cofactor in the synthesis of DNA. Folate deficiency may be caused by any of the following:

  • Dietary deficiency
  • Increased requirements of pregnancy
  • Congenital deficiency
  • Sprue
  • Alcoholism
  • Increased turnover due to conditions such as hemolysis or sickle cell disease, among others

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