What are the treatment options for diuretic-induced hypomagnesemia?

Updated: Oct 30, 2020
  • Author: Tibor Fulop, MD, PhD, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Patients with diuretic-induced hypomagnesemia who cannot discontinue diuretic therapy may benefit from the addition of a potassium-sparing diuretic (eg, amiloride or triamterene) or from changing plain thiazide-type diuretic medications to thiazide diuretic/potassium-sparing diuretic combinations. These drugs may decrease magnesium excretion by increasing its reabsorption in the collecting tubule. These drugs also may be useful in Bartter and Gitelman syndrome or in cisplatin nephrotoxicity.

These patients should also be placed on a magnesium-rich diet, which includes such foods as meat, green vegetables, dairy products, nuts, cereals, and seafood. In addition, these patients should be examined frequently for evidence of magnesium deficiency and should be monitored for regular serum magnesium. If hypomagnesemia persists, these patients should be treated with an oral sustained-release preparation.

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