What is the role of sulfate ions in the treatment of hypomagnesemia?

Updated: Oct 30, 2020
  • Author: Tibor Fulop, MD, PhD, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Sulfate ions also cause the generation of more negative transepithelial potential difference in renal tubules, which promotes kaliuresis and thereby can worsen hypokalemia. Patients undergoing intravenous magnesium replacement should be monitored for evidence of acute hypermagnesemia (eg, respiratory depression, areflexia). Patients with renal dysfunction are particularly at increased risk for hypermagnesemia during treatment, and only 25-50% of the normal dose magnesium dose should be given to patients when plasma creatinine levels are greater than 2 mg/dL.

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