What causes renal magnesium wasting?

Updated: Oct 30, 2020
  • Author: Tibor Fulop, MD, PhD, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Other causes of renal magnesium wasting, and the likely mechanisms, include the following:

  • Aldosterone excess - Chronic volume expansion, thereby increasing magnesium excretion
  • Hypercalcemia - Stimulation of the CaSR and inhibition of magnesium reabsorption
  • Hypophosphatemia - Unknown
  • Alcohol ingestion -  Alcohol-induced tubular dysfunction (which is reversible within 4 weeks of abstinence) [84]

Finally, magnesium wasting can be seen as part of the tubular dysfunction that is observed with recovery from acute tubular necrosis or during a postobstructive diuresis.

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