Which conditions cause hypomagnesemia due to renal magnesium loss?

Updated: Oct 30, 2020
  • Author: Tibor Fulop, MD, PhD, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Causes related to renal magnesium loss include the following, including inherited renal tubular defects [17, 19, 76, 77] and drugs [78] :

  • Gitelman syndrome
  • Classic Bartter syndrome (type III Bartter syndrome)
  • Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC)
  • Autosomal-dominant hypocalcemia with hypercalciuria (ADHH)
  • Isolated dominant hypomagnesemia (IDH) with hypocalciuria
  • Isolated recessive hypomagnesemia (IRH) with normocalcemia
  • HSH
  • Diuretics - Loop diuretics, osmotic diuretics, and long-term use of thiazides
  • Antimicrobials - Amphotericin B, aminoglycosides, pentamidine, capreomycin, viomycin, foscarnet
  • Chemotherapeutic agents - Cisplatin, cetuximab [79]
  • Immunosuppressants - Tacrolimus, cyclosporine
  • Proton-pump inhibitors [80, 81, 82]
  • Ethanol [84]
  • Hypercalcemia
  • Chronic metabolic acidosis
  • Volume expansion
  • Primary hyperaldosteronism
  • Recovery phase of acute tubular necrosis
  • Postobstructive diuresis

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