What is the role of hypomagnesemia in the etiology of diabetes?

Updated: Oct 30, 2020
  • Author: Tibor Fulop, MD, PhD, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Patients with diabetes mellitus are often magnesium deficient, expressed by hypomagnesemia. [59, 60, 61, 62] Magnesium deficiency decreases insulin sensitivity and secretion. [63, 64] Moreover, magnesium deficiency is inherently related to the pathogenesis and development not only of diabetic microangiopathy but also of lifestyle-related diseases, such as hypertension and hyperlipidemia. [65, 66] Magnesium deficiency may be a link with both inflammation or vascular stiffness in certain populations. [67, 68]

Generally, modern people tend to live in a state of chronic dietary magnesium deficiency. [69] There is a possibility that one of the major factors contributing to the drastic increase of type 2 diabetes mellitus is the drastically decreased intake of grains, such as barley or cereals rich in magnesium. [70] This implies an association between the volume of dietary magnesium intake and the onset of type 2 diabetes, raising expectations that in the future, clinical trials will be performed to investigate the efficacy of magnesium supplementation therapy.

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