Which medications in the drug class Antineoplastic Agents are used in the treatment of X-linked Lymphoproliferative Syndrome?

Updated: Jan 27, 2019
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Antineoplastic Agents

Antineoplastic agents inhibit cell growth and proliferation.

Etoposide (VePesid, VP-16)

Topoisomerase II inhibitor that leads to single-strand DNA breaks and cell cycle arrest. Has activity in a number of tumors, including small cell lung cancer, germ cell tumors, and lymphoma.

One reported case used 200 mg/m2/d IV for 3 d during acute EBV infection in a boy aged 6 years. Led to dramatic, although temporary, improvement. Little data support etoposide therapy in this syndrome.


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