What is included in the long-term monitoring of X-linked lymphoproliferative (XLP) syndrome?

Updated: Jan 27, 2019
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Close monitoring of EBV viral loads is important in to allow the prevention of recurrent infections, organ damage such as bronchiectasis, and permit early treatment of EBV infection and more serious complications. [6]  No formal surveillance guidelines exist; the following are general considerations [13] :

  • Blood should be monitored by EBV-PCR for evidence of EBV infection if symptoms of infection or HLH develop.
  • Blood counts, hepatic profiles, coagulation studies, and inflammatory markers (ferritin, soluble IL2R) should be monitored as needed based on clinical status for early evidence of HLH.
  • IgG levels should also be monitored as needed based on clinical phenotype.

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