How is X-linked lymphoproliferative (XLP) syndrome treated?

Updated: Jan 27, 2019
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Patients with dysgammaglobulinemia or recurrent infections due to X-linked lymphoproliferative (XLP) syndrome may benefit from immunoglobulin replacement therapy. This can be delivered intravenously every few weeks or subcutaneously every week, which is usually performed at home. Other manifestations of dysregulation, such as aplastic anemia or vasculitis, may respond to treatment with corticosteroids or other immunosuppressive agents. [6]

Colitis associated with XLP type 2 (XLP2) is treated symptomatically and with immunosuppression similar to that used for irritable bowel disease. [13]


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