What are the FDA approved uses of onabotulinumtoxinA (BOTOX) injections to treat bladder overactivity?

Updated: Mar 06, 2019
  • Author: Pamela I Ellsworth, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Intradetrusor injection of onabotulinumtoxinA is approved by the FDA for the treatment of urinary incontinence due to detrusor overactivity associated with a neurologic condition in adults who have an inadequate response to or are intolerant of an anticholinergic medication. Clinical trials have been performed in patients with multiple sclerosis and spinal cord injury. In such individuals, botulinum toxin A was used as monotherapy or in conjunction with anticholinergic therapy. More recently, onabotulinumtoxinA has been approved for the treatment of overactive bladder in patients who are refractory to or intolerant of anticholinergic agents.


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