What are the ESMO guidelines on post-treatment evaluation of primary mediastinal B-cell lymphoma (PMBCL)?

Updated: Sep 14, 2019
  • Author: Sonali M Smith, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Due to the high frequency of false-positive scans, ESMO recommends further investigaton of a positive PET scan before modifying planned therapy.  A post-treatment PET/CT response evaluation should not be carried out until at least 5–6 weeks from the last infusion of chemotherapy to minimise the incidence of false-positive scans. Serial scanning may be required to fully evaluate areas of residual post-treatment PET tracer uptake, with many patients manifesting gradual resolution. [36]


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