What is the role of lab testing in the workup of primary mediastinal B-cell lymphoma (PMBCL)?

Updated: Sep 14, 2019
  • Author: Sonali M Smith, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Perform a CBC count with differential and platelets. Perform an electrolyte panel and liver function tests.

Elevation in the serum lactic dehydrogenase (LDH) or beta-2 microglobulin level value is an adverse prognostic feature and usually is seen in the majority of patients.

The markers alpha-fetoprotein and beta-human chorionic gonadotropin (beta-hCG) are often highly elevated in patients with mediastinal germ cell tumors, constituting an important differential diagnosis in males.


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