Which medications in the drug class Alpha-adrenergic Agonists are used in the treatment of Tetralogy of Fallot (TOF) in Adults?

Updated: Nov 13, 2018
  • Author: Shabir Bhimji, MD, PhD; Chief Editor: Yasmine S Ali, MD, FACC, FACP, MSCI  more...
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Alpha-adrenergic Agonists

Alpha-adrenergic agents improve hemodynamic status by improving myocardial contractility and increasing heart rate, resulting in increased cardiac output. Peripheral resistance is increased by vasoconstriction, increased cardiac output, and elevated blood pressure.


Phenylephrine is a strong postsynaptic alpha-receptor stimulant with little beta-adrenergic activity. This drug produces vasoconstriction of arterioles, thereby increasing peripheral venous return.

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