What is the role of lab testing in the workup of tetralogy of Fallot (TOF) in adults?

Updated: Nov 13, 2018
  • Author: Shabir Bhimji, MD, PhD; Chief Editor: Yasmine S Ali, MD, FACC, FACP, MSCI  more...
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Laboratory studies that may be helpful in the evaluation of adult patients with tetralogy of Fallot (TOF) include the following:

  • Complete blood cell (CBC) count: Some patients may have a mild anemia, but if cyanosis is absent, polycythemia is rare.

  • Coagulation profile: This may be abnormal in patients with cyanosis and bleeding.

  • Arterial blood gas (including serum lactate, base excess, oxygen partial pressure [PO2]): The patient's oxygenation status, serum lactate levels, and base excess value appear to be prognostic markers for mortality in those undergoing surgical repair of tetralogy of Fallot. [4]

  • Blood cultures: Obtain blood cultures in febrile patients to rule out endocarditis or sepsis.

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