What is the prognosis of lymphoblastic lymphoma?

Updated: Sep 10, 2019
  • Author: Joseph M Tuscano, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

With current treatments, the overall survival rate at 5 years in children with lymphoblastic lymphoma is 80-90%, and the overall survival rate in adults is 45-55%. Disease-free survival rates at 5 years range from 70% to 90% in children and from 45% to 55% in adults. [2]

Treatment response rates in adults with lymphoblastic lymphoma range from 55-95%, with leukemia-type regimens producing rates higher than 70%. The 5-year disease-free survival rate is 45-55% in adults and 70-90% in children. Since 1982, increasing use of leukemia-type regimens has increased the 5-year overall survival rate from 26% to 45% in adults lymphoblastic lymphoma.

For any non-Hodgkin lymphoma (NHL), the prognosis for survival may be estimated according to the International Index. This index scores 1 point each for age older than 60 years, high serum LDH level, poor performance status, or tumor stage III or IV. Patients older than 60 years with more than 1 extranodal site receive an additional point. Five-year overall survival rates by index risk factor score are as follows:

  • 0 (zero) points – Low risk (83%)

  • 1 point – Low-intermediate risk (69%)

  • 2 points – Intermediate-high risk (46%)

  • 3 or more points – High risk (32%)

Relapse may occur locally or in extranodal sites such as the bone marrow or CNS.


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