Which factors affect the prognosis of lymphoblastic lymphoma?

Updated: Sep 10, 2019
  • Author: Joseph M Tuscano, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Identification of prognostic factors for patients with lymphoblastic lymphoma has been inconsistent in part because of the lack of a clear distinction between acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma, as well as distinguishing between adult and pediatric cases. Based on the potential for early treatment intensification, identification of reliable prognostic factors for clinical trial risk stratification is crucial. [10] Some of the commonly used prognostic factors are as follows:

  • Age older than 30 years

  • Advanced Ann Arbor stage (stage III or IV)

  • Bone marrow involvement

  • Central nervous system (CNS) involvement

  • Peripheral blood involvement/leukemic component

  • B symptoms

  • Advanced international prognostic index score more than 2

  • Time to achieve a complete response

  • Lactate dehydrogenase (LDH) level that is more than 1.5 times normal


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