Which clinical history findings are characteristic of lymphoblastic lymphoma?

Updated: Sep 10, 2019
  • Author: Joseph M Tuscano, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

As many as 75% of patients with T-cell lymphoblastic lymphoma will present with an anterior mediastinal mass, which may manifest as dyspnea, wheezing, stridor, dysphagia, or swelling of the head and neck. [9] B-cell subtypes usually lack a mediastinal mass. [10]

Constitutional B symptoms include any of the following:

  • Fever higher than 38°C

  • Drenching night sweats

  • Weight loss of more than 10% of body weight within 6 months

Patients may have fatigue from anemia or bleeding and bruising from thrombocytopenia; dyspnea or chest pain may result from pleural disease; neurologic deficits may be present from central nervous system (CNS) disease; and patients may have a gonadal mass or gonadal dysfunction.


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