What are the NCCN guidelines on the diagnosis of mycosis fungoides/Sezary syndrome (MF/SS)?

Updated: Feb 25, 2021
  • Author: Sanjay Vinjamaram, MD, MPH; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The NCCN recommends the following studies to establish a diagnosis of MF/SS [26] :

  • Immunohistochemistry panel of skin biopsy: CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, CD25, CD56, T1A1, granzyme B, βF1, TCR-CyM1

  • Molecular analysis of skin biopsy: TCR gene rearrangements by polymerase chain reaction (PCR)

  • Assessment of peripheral blood for Sezary cells

  • Biopsy of suspicious lymph nodes (in absence of definitive skin diagnosis)

  • Assessment of HTLV-1 serology in at-risk populations


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