What are the NCCN and ESMO guidelines on the diagnosis of gastric MALT lymphoma?

Updated: Feb 25, 2021
  • Author: Sanjay Vinjamaram, MD, MPH; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In addition to its general guidance on diagnosis of lymphoma, the National Comprehensive Cancer Network (NCCN) recommends the following studies to establish a diagnosis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma [26] :

  • Immunohistochemistry panel: CD20, CD3, CD5, CD10, BCL2, kappa/lambda, CD21 or CD23, BCL6, cyclin D1

  • Cell surface marker analysis by flow cytometry: kappa/lambda, CD19, CD20, CD5, CD23, CD10

  • Helicobacter pylori testing

  • Fluorescence in situ hybridization (FISH) or polymerase chain reaction (PCR) for detection of t(11;18) (p21;p21) to identify patients who are unlikely to respond to antibiotic therapy

European Society for Medical Oncology (ESMO) guidelines for clinical management of marginal zone lymphomas of MALT type provide similar recommendations. [74]


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