What is the FLIPI2 index for follicular lymphoma (FL) risk stratification?

Updated: Feb 25, 2021
  • Author: Sanjay Vinjamaram, MD, MPH; Chief Editor: Emmanuel C Besa, MD  more...
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In 2009, the International Follicular Lymphoma Prognostic Factor Project published an updated score, FLIPI2. The FLIPI2 includes the following risk factors (as with FLIPI1, each factor is worth 1 point) [69] :

  • Age >60y

  • β2-microglobulin (B2M) above the upper limit of normal

  • Bone marrow involvement

  • Hemoglobin level < 12 g/dL

  • Longest diameter of the largest involved node >6 cm

Based on the FLIPI2 score, patients can be categorized as follows [69] :

  • Low risk (0 or 1 point)

  • Intermediate risk (2 points)

  • High risk (≥3 points)

With this model, relapse-free and overall survival rates at 5 years are as follows [69] :

  • 0-1 risk factors - 79%

  • Two risk factors - 51%

  • Three or more risk factors - 20%

FLIPI1 and FLIPI2 are used to predict prognosis but are not used to select treatment options.

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