What are the NCCN recommendations for follicular lymphoma (FL) risk stratification?

Updated: Feb 25, 2021
  • Author: Sanjay Vinjamaram, MD, MPH; Chief Editor: Emmanuel C Besa, MD  more...
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The NCCN recommends both the GELF criteria and the 2004 Follicular Lymphoma International Prognostic Index (FLIPI) for risk stratification. The FLIPI includes the following risk factors [11] :

  • Age >60 y

  • Ann Arbor Stage III-IV

  • Lactate dehydrogenase (LDH) level above the upper limit of normal

  • Hemoglobin level < 12 g/dL

  • Four or more nodal sites of disease

For each factor, the patient receives 1 point. Based on the FLIPI score, patients can be categorized as follows [11] :

  • Low risk (0 or 1 point)

  • Intermediate risk (2 points)

  • High risk (≥3 points)

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