Which studies are performed in the diagnostic workup of non-Hodgkin lymphoma (NHL)?

Updated: Feb 25, 2021
  • Author: Sanjay Vinjamaram, MD, MPH; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The workup in a patient with suspected non-Hodgkin lymphoma (NHL) should include the following:

  • Complete blood cell (CBC) count

  • Serum chemistry studies, including lactate dehydrogenase (LDH)

  • Serum beta2-microglobulin level

  • HIV serology

  • Chest radiography

  • Computed tomography (CT) scan of the neck, chest, abdomen, and pelvis

  • Positron emission tomography (PET) scan

  • Excisional lymph node biopsy

  • Bone marrow aspirate and biopsy

  • Hepatitis B testing in patients in whom rituximab therapy is planned because reactivation has been reported

Other studies may be indicated, depending on the clinical presentation.


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