Which factors affect the prognosis of non-Hodgkin lymphoma (NHL)?

Updated: Feb 25, 2021
  • Author: Sanjay Vinjamaram, MD, MPH; Chief Editor: Emmanuel C Besa, MD  more...
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The prognosis for patients with NHL depends on the following factors:

  • Tumor histology (based on Working Formulation classification)
  • Tumor stage
  • Patient age
  • Tumor bulk
  • Performance status
  • Serum lactate dehydrogenase (LDH) level
  • Beta2-microglobulin level
  • Presence or absence of extranodal disease

In general, these clinical characteristics are thought to reflect the following host or tumor characteristics:

  • Tumor growth and invasive potential (eg, LDH, stage, tumor size, beta2-microglobulin level, number of nodal and extranodal sites, bone marrow involvement)
  • Patient's response to tumor (eg, performance status, B symptoms)
  • Patient's tolerance of intensive therapy (eg, performance status, patient age, bone marrow involvement)

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