What are the signs and symptoms of intermediate- and high-grade non-Hodgkin lymphoma (NHL)?

Updated: Feb 25, 2021
  • Author: Sanjay Vinjamaram, MD, MPH; Chief Editor: Emmanuel C Besa, MD  more...
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Intermediate- and high-grade lymphomas have a more varied clinical presentation, including the following:

  • Adenopathy: Most patients

  • Extranodal involvement: More than one third of patients; most common sites are GI/GU tracts (including Waldeyer ring), skin, bone marrow, sinuses, thyroid, CNS

  • B symptoms: Temperature >38°C, night sweats, weight loss >10% from baseline within 6 months; in approximately 30-40% of patients

See Presentation for more detail.

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