What are the signs and symptoms of low-grade non-Hodgkin lymphoma (NHL)?

Updated: Feb 25, 2021
  • Author: Sanjay Vinjamaram, MD, MPH; Chief Editor: Emmanuel C Besa, MD  more...
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Signs and symptoms of low-grade lymphomas include the following:

  • Peripheral adenopathy: Painless and slowly progressive; can spontaneously regress

  • Primary extranodal involvement and B symptoms: Uncommon at presentation; however, common with advanced, malignant transformation or end-stage disease

  • Bone marrow: Frequent involvement; may be associated with cytopenias(s) [1] ; fatigue/weakness more common in advanced-stage disease

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