What is the role of fludarabine in mantle cell lymphoma (MCL) treatment?

Updated: Mar 15, 2019
  • Author: Muhammad Rashid Abbasi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Fludarabine as a single agent has demonstrated activity in MCL. It has been used, with or without rituximab, in the following combinations:

  • Fludarabine, mitoxantrone, and dexamethasone (FND)
  • Fludarabine and cyclophosphamide (FC) [16]
  • Fludarabine, cyclophosphamide, mitoxantrone (FCM)

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