What is the CVP chemotherapy regimen for mantle cell lymphoma (MCL)?

Updated: Mar 15, 2019
  • Author: Muhammad Rashid Abbasi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

A randomized prospective trial that compared CVP with CHOP showed no advantage of adding doxorubicin, with similar response and survival rates. In some retrospective analyses, doxorubicin-containing regimens were associated with a longer event-free survival.

CVP is administered every 21 days, in the following regimen:

  • Cyclophosphamide at 400 mg/m 2/d PO days 1-5 or 750-1000 mg/m 2 IV on day 1
  • Vincristine at 1.4 mg/m 2 IV on day 1, not to exceed 2 mg
  • Prednisone at 100 mg/m 2/d PO on days 1-5

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