Which therapies are used in the treatment of primary mantle cell lymphoma (MCL)?

Updated: Mar 15, 2019
  • Author: Muhammad Rashid Abbasi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Primary MCL therapy may consist of the following:

  • Single akylating agents
  • CVP (cyclophosphamide, vincristine, prednisone)
  • CHOP (cyclophosphamide, doxorubicin [hydroxydaunorubicin], vincristine [Oncovin], prednisone)
  • Hyper-CVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin [Adriamycin], dexamethasone) with or without rituximab
  • R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone)
  • Lenalidomide plus rituximab [11]
  • Hyper-CVAD with autologous stem cell transplantation

A study by Griffiths et al found that the addition of rituximab to a standard first-line chemotherapy regimen significantly improved survival in older patients (mean age, 75 y) with MCL. [12]


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