What are the immunophenotyping characteristics of mantle cell lymphoma (MCL)?

Updated: Mar 15, 2019
  • Author: Muhammad Rashid Abbasi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

On immunophenotyping, tumor cells in MCL are monoclonal B cells with the following characteristics:

  • Express surface immunoglobulin, immunoglobulin M, or immunoglobulin D

  • Are characteristically CD5+ and pan B-cell antigen positive (eg, CD19, CD20, CD22)

  • Lack expression of CD10 and CD23

  • Overexpress cyclin D1


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