Which clinical history findings are characteristic of mantle cell lymphoma (MCL)?

Updated: Mar 15, 2019
  • Author: Muhammad Rashid Abbasi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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The male-to-female ratio in MCL is 3:1, and the age range at presentation is 35-85 years, with a median of 68 years. Findings on the history include the following:

  • Stage IV disease in 70% of patients

  • B symptoms, which include fever, night sweats, and weight loss, in 40% of patients

  • Generalized lymphadenopathy

  • Abdominal distention from hepatosplenomegaly

  • Fatigue from anemia or bulky disease

  • Less common symptoms caused by extranodal involvement of GI tract, lungs, and CNS

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