What is the role of intrathecal chemotherapy in the treatment of diffuse large B-cell lymphoma (DLBCL)?

Updated: Aug 20, 2020
  • Author: Shipra Gandhi, MBBS; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Routine intrathecal chemotherapy is strongly recommended in patients with DLBCL with the following characteristics:

  • Two or more extranodal sites of disease
  • Testicular or breast involvement, regardless stage
  • Lymphoblastic variants
  • Oropharyngeal or paraspinal sites of involvement
  • Bone marrow involvement
  • Concomitant infection with human immunodeficiency virus (HIV)

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