Which clinical history findings are characteristic of diffuse large cell lymphoma?

Updated: Jun 12, 2019
  • Author: Shipra Gandhi, MBBS; Chief Editor: Emmanuel C Besa, MD  more...
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The clinical manifestations of diffuse large cell lymphomas are diverse and depend on the site of disease involvement. These tumors have a rapid growth rate and present as masses, causing symptoms when they infiltrate tissues or obstruct organs. Pain in an enlarged lymph node or organ may be noted if the lymphomatous mass enlarges rapidly.

As with other types of non-Hodgkin lymphoma (NHL), diffuse large cell lymphomas can present with B-symptoms, including fever, drenching night sweats, and weight loss. Generalized pruritus may also be present.

Other symptoms can include the following:

  • Anorexia

  • Pedal edema - Caused by extensive pelvic lymphadenopathy

  • Fatigue

  • Chest discomfort or shortness of breath - Caused by mediastinal lymphadenopathy

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