How is diffuse large cell lymphoma classified?

Updated: Jun 12, 2019
  • Author: Shipra Gandhi, MBBS; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Considerable progress has been made in NHL classification.In 1982, the National Cancer Institute introduced the International Working Formulation, a translation system for other, older classifications, including the Rappaport and the immunologically oriented Lukes-Collins and Kiel systems. The working formulation provided a conceptual framework that groups lymphomas as low grade (indolent), intermediate grade, or high grade, with respect to their natural histories. [3]

In 1994, the International Lymphoma Study Group proposed the REAL classification schema. [4] It classifies NHLs as being derived from B or T/NK cells, and it includes disease entities that were not part of the working formulation.


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