What are the signs and symptoms of diffuse large B-cell lymphoma (DLBCL)?

Updated: Aug 20, 2020
  • Author: Shipra Gandhi, MBBS; Chief Editor: Emmanuel C Besa, MD  more...
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DLBCLs have a rapid growth rate and present as masses infiltrating tissues or obstructing organs. Signs and symptoms include the following:

  • Pain in an enlarged lymph node or organ: May be noted if the lymphomatous mass enlarges rapidly
  • B symptoms (Ann Arbor staging): Including fever, drenching night sweats, and weight loss
  • Generalized pruritus
  • Anorexia
  • Pedal edema: Caused by extensive pelvic lymphadenopathy
  • Fatigue
  • Chest discomfort or shortness of breath: Caused by mediastinal lymphadenopathy

The following are common findings on physical examination:

  • Lymphadenopathy (ie, cervical, axillary, and inguinal)
  • Splenomegaly
  • Low-grade fever
  • Pedal edema: Resulting from extensive pelvic lymphadenopathy

See Presentation for more detail.

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