Which medications in the drug class Antiemetics/Sedatives are used in the treatment of Ovarian Torsion?

Updated: Jun 27, 2017
  • Author: Erik D Schraga, MD; Chief Editor: Eugene C Lin, MD  more...
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Answer

Antiemetics/Sedatives

Antiemetics are useful in the treatment of nausea associated with the clinical symptoms of ovarian torsion. Some antiemetics also have sedative effects.

Prochlorperazine (Compazine, Compro)

Prochlorperazine may relieve nausea and vomiting by blocking postsynaptic mesolimbic dopamine receptors through its anticholinergic effects and depressing the reticular activating system. In addition to its antiemetic effects, it has the advantage of augmenting hypoxic ventilatory response, acting as a respiratory stimulant at high altitude.

Metoclopramide (Reglan, Metozolv)

Metoclopramide blocks dopamine receptors in the chemoreceptor trigger zone of the central nervous system.

Ondansetron (Zofran, Zuplenz)

Ondansetron is a selective 5-HT3-receptor antagonist that blocks serotonin both peripherally and centrally. It prevents the nausea and vomiting associated with emetogenic cancer chemotherapy (eg, high-dose cisplatin) and complete-body radiotherapy.


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