Which studies are recommended to establish a diagnosis of B-cell Burkitt lymphoma (BL)?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In addition to its general guidance on diagnosis of lymphoma, the National Comprehensive Cancer Network (NCCN) recommends the following studies to establish a diagnosis of Burkitt lymphoma [27] :

  • Immunohistochemistry panel: CD45(LCA), CD20, CD3, BCL2, BCL6, Ki-67, TdT  or
  • Cell surface marker analysis by flow cytometry: kappa/lambda, CD45, CD20, CD3, CD5, CD19, CD10, TdT
  • Fluorescence in situ hybridization (FISH) or cytogenetics for detection of  t(8;14),  MYC
  • Epstein-Barr encoding region in situ hybridization (EBER-ISH) can be used to identify EBV

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