What is the first-line therapy for the treatment of diffuse large B-cell lymphoma (DLBCL)?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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National Comprehensive Cancer Network recommendations  [27]

First-line therapy (in alphabetical order) options are as follows:

  • R-CHOP (rituximab, cyclophosphamide, doxorubicin [hydroxydaunorubicin], vincristine, prednisone) (category1)
  • Dose-dense R-CHOP (category 3)
  • Dose-adjusted EPOCH (etoposide, prednisone, vincristine [Oncovin], cyclophosphamide, doxorubicin) + rituximab (category 2B)

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