What is the risk stratification for B-cell mantle cell lymphoma (MCL)?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The European Society for Medical Oncology (ESMO) recommends the combined MCL International Prognostic Index (cMIPI) for risk stratification. [31]  The MIPI includes the following risk factors [12] :

  • Age: 50-59 (1 point); 60-69 (2 points); ≥70 (3 points)
  • Eastern Cooperative Oncology Group (ECOG) performance status 2-4 (2 points)
  • Lactate dehydrogenase level (ratio to upper limit of normal): 0.67-0.99 (1 point); 1.00-1.49 (2 points); ≥1.50 (3 points)
  • White blood cell count (× 10 9/L): 6700-9999 (1 point); 10,000-14,999 (2 points); ≥15,000 (3 points)

An Internet-based cMIPI calculator is available web-based calculator: www.european-mcl.net/de/clinical_mipi.php.


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