What are the options for second-line consolidation or extended dosing in the treatment of B-cell follicular lymphoma?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Options for second-line consolidation or extended dosing (optional) include the following:

  • Rituximab maintenance – 375 mg/m ,one dose every 12 wk for 2 years (category 1)
  • Obinutuzumab maintenance for rituximab-refractory disease (1 g every 8 wk for total of 12 doses)
  • High-dose therapy with autologous stem cell rescue
  • Allogeneic stem cell transplant for highly selected patients

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