What are the FLIPI2 risk stratification factors for NHL/B-cell follicular lymphoma?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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In 2009, the International Follicular Lymphoma Prognostic Factor Project published an updated score, FLIPI2. The FLIPI2 includes the following risk factors (as with FLIPI1, each factor is worth 1 point) [10] :

  • Age >60y
  • β2-microglobulin (B2M) above the upper limit of normal
  • Bone marrow involvement
  • Hemoglobin level <12 g/dL
  • Longest diameter of the largest involved node >6 cm

Based on the FLIPI2 score, patients can be categorized as low, intermediate, or high risk. [10]

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