What are the FLIPI risk stratification factors for NHL/B-cell follicular lymphoma?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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The NCCN recommends both the GELF criteria and the 2004 Follicular Lymphoma International Prognostic Index (FLIPI) for risk stratification. The FLIPI includes the following risk factors [11] :

  • Age >60 y
  • Ann Arbor Stage III-IV
  • Lactate dehydrogenase (LDH) level above the upper limit of normal
  • Hemoglobin level <12 g/dL
  • Five or more nodal sites of disease

For each factor, the patient receives 1 point. Based on the FLIPI score, patients can be categorized as follows [11] :

  • Low risk (0 or 1 point)
  • Intermediate risk (2 points)
  • High risk (≥3 points)

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