What are the GELF criteria for immediate therapy in NHL/B-cell follicular lymphoma?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The Groupe d’Etude des Lymphomes Folliculaires (GELF) recommends the following criteria for identifying patients in whom immediate therapy is necessary [29] :

  • Involvement of ≥3 nodal sites, each with a diameter of ≥3 cm
  • Any nodal or extranodal tumor mass with a diameter of ≥7 cm
  • B symptoms
  • Splenomegaly
  • Pleural effusions or peritoneal ascites
  • Cytopenias (leukocytes < 1.0 x 10 9/L and/or platelets < 100 x 10 9/L)
  • Leukemia (>5.0 x 10 9/L malignant cells)

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