Which studies does the NCCN recommend for the diagnosis of B-cell follicular lymphoma (FL)?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In addition to its general guidance on diagnosis of lymphoma, the NCCN recommends the following studies to establish a diagnosis of FL [16] :

  • Immunohistochemistry panel: CD20, CD3, CD5, CD10, BCL2, BCL6, cyclin D1, CD21, or CD23
  • Cell surface marker analysis by flow cytometry: kappa/lambda, CD19, CD20, CD5, CD23, CD10
  • Molecular analysis to detect: antigen receptor gene rearrangements; BCL2 rearrangements
  • Karyotype or FISH: t(14;18); BCL6, 1p36, IRF4/MUM1 rearrangements
  • Immunohistochemistry panel: Ki-67; IRF4/MUM1 for FL grade 3, cyclin D1

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