What is the role of an immunoglobulin (Ig) gene rearrangement in the workup of NHL/B-cell lymphoma?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Immunoglobulin (Ig) gene rearrangement is useful for differentiating a B-cell lymphoproliferative process from a monoclonal or reactive proliferation of lymphocytes. This technique not only provides a specific marker for B cells but also is a true marker for monoclonality.

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