Which tests are indicated in the workup of B-cell lymphoma of germinal center origin?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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For the workup of any high-grade B-cell lymphoma of germinal center origin, fluorescence in situ hybridization (FISH) studies for evaluation of myc, bcl-6, and bcl-2 rearrangements should typically be ordered, in order to establish classification of "double hit" lymphomas. Double hit B-cell lymphomas are a specific subtype of diffuse large B-cell lymphoma (DLBCL) that have a much more aggressive clinical course and are associated with translocations of two of the three oncogenes (myc, bcl-2, and bcl-6).

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