What is the pathogenesis of B-cell lymphoma?

Updated: Feb 23, 2021
  • Author: Mohammad Muhsin Chisti, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

Non-random chromosomal and molecular rearrangements (see the table below) play an important role in the pathogenesis of many lymphomas and correlate with histology and immunophenotype.

Table 1. Chromosomal Abnormalities in B-Cell Non-Hodgkin Lymphoma (Open Table in a new window)

Cytogenetic Abnormality

Histology

Antigen Rearrangement

Oncogene Expression

t(14;18)(q32;q21)

Follicular, diffuse large cell

IgH*

bcl- 2

t(11;14)(q13;q32)

Mantle cell

IgH

cyclin-D1/bcl-1

t(1;14)(p22;q32)

MALT lymphoma

IgH

bcl- 10

t(11;18)(q21;q21)

MALT lymphoma

IgH

Unknown

t(9;14)(p13;q32)

Lymphoplasmacytic lymphoma

IgH

PAX-5

8q24 translocations

t(8;14)(q24;q32)

t(2;8)(p11-12;q24)

t(8;22)(q24;q11)

Burkitt lymphoma

IgH

Ig-8

Ig-6

c-myc

Trisomy 12, deletion 11q22-23, 17p13, and 6q21

CLL

*Immunoglobulin H (IgH)

MALT = Mucosa-associated lymphoid tissue.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!