Which histologic findings are characteristic of light-chain deposition disease (LCDD)?

Updated: Sep 26, 2019
  • Author: Swapna Boppana, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The electron microscopic changes characteristic of light-chain deposition disease (LCDD) demonstrate finely granular, electron-dense deposits in the mesangial nodules and along the endothelial aspect of the glomerular basement membrane. [17, 18, 36] In cases of tubular involvement, the deposits are noted along the outer aspect of the membrane.


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