What is the role of biopsy in the workup of light-chain deposition disease (LCDD)?

Updated: Sep 26, 2019
  • Author: Swapna Boppana, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Biopsy procedures are as follows:

  • Biopsy of the specific organ suspected of involvement, with immunohistochemical staining for kappa and lambda chains

  • Rectal biopsy or subcutaneous fat aspiration to exclude amyloidosis

  • Bone marrow aspiration and biopsy to rule out multiple myeloma


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