What is the role of osmotic fragility testing (OFT) in the diagnosis of iron deficiency anemia?

Updated: Aug 04, 2019
  • Author: James L Harper, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

Incubated osmotic fragility is useful. Microspherocytosis may produce a low-normal or slightly abnormal MCV; however, the MCHC usually is elevated rather than decreased, and the peripheral smear shows a lack of central pallor rather than hypochromia. Spherocytosis can normally be separated from iron deficiency anemia by peripheral blood smear.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!